Aesthetic method of biological structure treatment by magnetic field

ABSTRACT

In methods for treating a patient, a time varying magnetic field is applied to a patient&#39;s body and causes a muscle contraction. The time-varying magnetic field may be monophasic, biphasic, polyphasic and/or static. The method may reduce adipose tissue, improve metabolism, blood and/or lymph circulation. The method may use combinations of treatments to enhance the visual appearance of the patient.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is a Continuation of U.S. patent application Ser. No.16/827,330, filed Mar. 23, 2020 and now pending, which is a Continuationof U.S. patent application Ser. No. 15/601,719, filed May 22, 2017 nowpatented as U.S. Pat. No. 10,596,386, which claims priority to each ofU.S. Provisional Patent Application Nos. 62/357,679 filed Jul. 1, 2016,62/440,905 filed Dec. 30, 2016, and 62/440,922 filed Dec. 20, 2016.These applications are incorporated herein by references.

FIELD OF THE INVENTION

The present invention generally relates to methods using the influenceof magnetic and induced electric field on biological structure. Themagnetic field is time-varying and high powered therefore the method isbased on a value of magnetic flux density sufficient to induce at leastpartial muscle contraction.

BACKGROUND OF THE INVENTION

Aesthetic medicine includes all treatments resulting in enhancing avisual appearance and satisfaction of the patient. Patients want tominimize all imperfections including body shape and effects of naturalaging. Indeed, patients request quick, non-invasive procedures providingsatisfactory results with minimal risks.

The most common methods used for non-invasive aesthetic applications arebased on application of mechanical waves, e.g. ultrasound or shock wavetherapy; or electromagnetic waves, e.g. radiofrequency treatment orlight treatment, such as intense pulsed light or laser treatment. Theeffect of mechanical waves on tissue is based especially on cavitation,vibration and/or heat inducing effects. The effect of applications usingelectromagnetic waves is based especially on heat production in thebiological structure.

Skin tissue is composed of three basic elements: epidermis, dermis andhypodermis or so called subcutis. The outer and also the thinnest layerof skin is the epidermis. The dermis consists of collagen, elastictissue and reticular fibers. The hypodermis is the lowest layer of theskin and contains hair follicle roots, lymphatic vessels, collagentissue, nerves and also fat forming a subcutaneous white adipose tissue(SWAT). The adipose cells create lobules which are bounded by connectivetissue, fibrous septa (retinaculum cutis).

Another part of adipose tissue, so called visceral fat, is located inthe peritoneal cavity and forms visceral white adipose tissue (VWAT)located between parietal peritoneum and visceral peritoneum, closelybelow muscle fibers adjoining the hypodermis layer.

Existing devices have low efficiency and they waste energy, which limitstheir use. Eddy currents induced within the coil create engineeringchallenges. Existing devices contain coils which are made of metallicstrips, electric wires or hollow conductors. Since the therapy requireslarge currents, significant losses are caused by induced eddy currentswithin the coil. Eddy currents lead to production of unwanted heat andtherefore there is need to sufficiently cool the coil. Also, the energysource must be protected during reverse polarity of resonance. Thisrequires using protective circuits which consume significant amounts ofenergy.

Current magnetic aesthetic methods are limited in key parameters whichare repetition rate and/or magnetic flux density. All known methods uselow values of magnetic flux density and/or low repetition rates whichdoes not allow satisfactory enhancement of visual appearance. As aresult, new methods are needed to enhance the visual appearance of thepatient.

The currently used aesthetic applications don't provide any treatmentcombining the effect of time-varying magnetic field treatment andconventional treatment, e.g. treatment by electromagnetic field such asradiofrequency treatment. The currently used radiofrequency treatmentincludes many adverse events such as non-homogenous thermal temperature,insufficient blood and/or lymph flow during and/or after the treatment.Additionally several adverse event such as panniculitis may occur afterthe treatment.

SUMMARY OF THE INVENTION

The present methods and devices as described below produce a timevarying magnetic field for patient treatment which better optimizesenergy use, increases the effectiveness of the treatments and provide anew treatment. The magnetic pulses may be generated in monophasic,biphasic or polyphasic regimes. In a first aspect, the device has one ormore coils; a switch; an energy storage device and a connection to anenergy source. The coil may be made of insulated wires with a conductordiameter less than 3 mm even more preferably less than 0.5 mm and mostpreferably less than 0.05 mm. Smaller diameter and individual insulationof the wires significantly reduces self-heating of the coil andtherefore increase efficiency of magnetic stimulation device. The coilmay be flexibly attached in a casing of device. The casing may comprisea blower or blowers which ensure cooling of the coil.

The present methods provide new aesthetic applications for focusedremodeling of the patient's body. The coil of the magnetic stimulationdevice may be flexibly attached to casing of the device. The blower orblowers may be arranged to blow air on both sides of coil. Optionally,the coil may be a flat type coil.

The method of treating a biological structure uses a combination ofnon-invasive methods for enhancing human appearance. The inventionutilizes electromagnetic field. Methods may be used for targetedremodeling of adipose tissue, focused treatment of cellulite, bodycontouring, skin tightening or skin rejuvenation. The invention relatesto focused heating of the target tissue by electromagnetic waves,whereas the effect of focused heating of the target tissue is amplifiedby the effect of a magnetic treatment.

The magnetic treatment induces the muscle contraction at higherrepetition rates and the contraction is stronger. Therefore thetreatment is more efficient for reducing the number and/or volume ofadipocytes and enhancing the visual appearance of the treated bodyregion via targeted muscle contraction. Further the temperaturehomogeneity of is improved. Additionally, strong muscle contractions athigher repetition rates cause mechanical movement of all the layers inproximity of the contracted muscle. The methods therefore causeremodeling and/or neogenesis of the collagen and elastin fibers.

The methods enable new treatments by magnetic and/or electromagneticfield. The repetition rate of the magnetic field is in the range of 1 to300 Hz with high magnetic flux density up to 7 Tesla (equivalent to70000 Gauss). The frequency of the electromagnetic field is 13.56 or40.68 or 27.12 MHz or 2.45 GHz.

Glossary

Conventional non-invasive and/or invasive aesthetic medicine treatmentmethods refer to aesthetic applications based on application ofmechanical waves, e.g. acoustic wave, ultrasound or shock wave therapy;or electromagnetic waves, e.g. radiofrequency or diathermy treatment orlight treatment, such as intense pulsed light or laser treatment; ormechanical stimulation, e.g. positive or negative pressure, rollerball,massage etc.; or thermal treatment, e.g. cryotherapy; or electrotherapymethod; or mesotherapy method and or any combination thereof.

Thermal treatment refers to treatment by heating or cooling, e.g. acryotherapy treatment.

Biological structure is at least one neuron, neuromuscular plate, musclefiber, adipose cell or tissue, collagen, elastin, pigment or skin.

Remodeling target biological structure refers to reducing the numberand/or volume of the adipocytes by apoptosis and/or necrosis, cellulitetreatment, body shaping and/or contouring, muscle toning, skintightening, collagen treatment, skin rejuvenation, wrinkle removing,reducing stretchmarks, breast lifting, lip enhancement, treatment ofvascular or pigmented lesions of the skin or hair removing.

Body region includes muscle or muscle group, buttocks, saddlebags, lovehandles, abdomen, hips, thighs, arms, limb and/or any other tissue.

Muscle includes at least one of muscle fiber, muscle tissue or group,neuromuscular plate or nerve innervating the at least one muscle fiber.

Deep muscle refers to a muscle that is at least partly below superficialmuscles and/or to the muscle that is covered by a thick layer of othertissue, e.g. mostly adipose tissue and/or the skin, with thickness 0.5,1, 2, 3, 4, 5 or more centimetres.

Adipose tissue refers to at least one lipid rich cell, e.g. adipocyte.

Bolus refers to a layer of fluid material, e.g. water or fluid solutionof ceramic particles, preferably enclosed in a flexible sac made ofbiocompatible material.

Impulse refers to a single magnetic stimulus.

Pulse refers to a period of treatment by a magnetic field of at leastone magnetic stimulus and time duration of no stimulation, i.e. timeduration between two impulses from rise/fall edge to next rise/falledge.

Repetition rate refers to frequency of firing the pulses; it is derivedfrom the time duration of a pulse.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a cross section view of a coil winding.

FIG. 2 is a cross-section of a magnetic applicator.

FIG. 3 is a side view of a casing of a magnetic applicator.

FIGS. 4A and 4B illustrate circuits for providing high power pulses to astimulating coil.

FIG. 5 is a graph showing voltage drop in the energy storage device.

FIG. 6 is a diagram of a biological effect.

FIGS. 7A and 7B illustrate diagrams of a treatment device.

DETAILED DESCRIPTION

FIG. 1 illustrates a cross section of winding of a coil for a magneticstimulation device. The coil may be constructed from litz-wire, whereineach wire is insulated separately. Each individual conductor is coatedwith non-conductive material so the coil constitutes multiple insulatedwires. Unlike existing magnetic coil conductors, the present coil is notmade of bare wire e.g. litz-wire without insulation, or conductivetapes, conductive strips, or copper pipe with hollow inductors. Theinsulation of wires separately is a substantial improvement, since thisleads to a significant reduction of the induced eddy currents. Powerloss due to eddy currents, per single wire, is described by Equation 1below. The small diameter of wires significantly reduces self-heating ofthe coil and therefore increases efficiency of the present magneticstimulation device.

$\begin{matrix}{{P_{EDDY} = \frac{\pi^{2} \cdot B_{P}^{2} \cdot d^{2} \cdot f^{2}}{6 \cdot k \cdot \rho \cdot D}},} & {{Eq}.1}\end{matrix}$

where: P_(EDDY) is power loss per unit mass (W·kg⁻¹); B_(p) is the peakof magnetic field (T); f is frequency (Hz); d is the thickness of thesheet or diameter of the wire (m); k is constant equal to 1 for a thinsheet and 2 for a thin wire; ρ is the resistivity of material (Ω·m); Dis the density of material (kg·m³).

The individual insulation of each wire reduces eddy currents. Theindividually insulated wires may be wound either one by one or in abundle of individually insulated wires so as to form a coil, which willserve as a magnetic field generator. The coil provides an improvement inthe efficiency of energy transfer in the LC resonant circuit and alsoreduces or eliminates unwanted thermal effects.

The coil may have a planar coil shape where the individually insulatedwires may have cross-section wires with conductor diameter less than 3mm even more preferably less than 0.5 mm and most preferably less than0.05 mm. The wires are preferably made of materials with higher densityand higher resistivity e.g. gold, platinum or copper. The diameters ofthe single wires should be minimal. On the other hand the total diametershould be maximal because of inverse proportion between thecross-section of all wires forming the coil and the electricalresistance. Therefore the ohmic part of the heat is then lower. Eq. 2describes power loss of the coil:

$\begin{matrix}{P_{R} = \frac{\rho \cdot \frac{l}{S} \cdot I^{2}}{m}} & {{Eq}.2}\end{matrix}$

Where: P_(R) is the power loss heat dissipation (W); ρ is the resistance(Ω·m); l is the length of wire (m); S is the surface area (m²); I is thecurrent (A) and m is 1 kg of wire material.

Total power loss is (Eq.3):

P _(TOT) =T _(EDDY) +P _(R),  Eq. 3

Where: P_(TOT) is the total power losses (W·kg⁻¹); P_(EDDY) is the powerdissipation of eddy currents (W·kg⁻¹); P_(R) is the power loss heatdissipation (W·kg⁻¹).

Dynamic forces produced by current pulses passing through the wires ofthe coil cause vibrations and unwanted noise. The individual insulatedwires of the coil may be impregnated under pressure so as to eliminateair bubbles between the individual insulated wires. The space betweenwires can be filled with suitable material which causes unification,preservation and electric insulation of the system. Suitable rigidimpregnation materials like resin, and elastic materials like PTE can bealso used. With the coil provided as a solid mass, the vibrations andresonance caused by movements of the individual insulated wires aresuppressed. Therefore noise is reduced.

The coil may be attached to the case of the applicator, such as a handheld applicator of the magnetic stimulation device; build-in applicatorin e.g. chair, bed; or stand-alone applicator e.g. on mechanicalfixture. The attachment may be provided by an elastic material e.g.,silicone, gum; or other flexible manner. Connection with the coil of theapplicator's case can be ensured by several points. The severalfastening points ensure the connection of the coil to the casing byflexible material so that the main part of the coil and the main part ofthe casing of applicator are spaced apart. The spacing should be atleast 0.1 mm so that air can easily flow. The gap between the coil andthe casing can be used either for spontaneous or controlled cooling. Thecoil may optionally be connected to the case of the applicator by onlyone fastening point. The fastening points eliminate vibrations of wireswhich could be transferred to housing of the applicator and thereforereduce noise of the magnetic stimulation device.

FIG. 2 is a cross-section of the magnetic applicator which allows betterflow on the lower and upper sides of the coil and thus more efficientheat dissipation. The magnetic stimulation device includes a coil 1, thecircuit wires 2 and the fastening points 3 for connection of the coil tothe casing of the applicator (not shown). The fastening points 3 arepreferably made of flexible material however the rigid material may beused as well. The fastening points 3 may be located on the outercircumferential side of the coil. However, alternatively it is possibleto put these fastening points to a lower or upper side of the coil.

The fastening points 3 connect the coil to the case of the applicator inat least one point. The fastening points 3 maintain the coil and themain part of the case of the applicator spaced apart so that fluid(which may be air or any liquid) can flow between them. At least oneblower 4 can be placed around the circumference of the coil, orperpendicular to the coil. The blower can be any known kind of devicefor directing the fluid e.g. outer air directed into the case of theapplicator. This arrangement of the blower allows air to bypass the coilfrom upper and lower (patient's) sides. In still another embodiment theouter air can be cooled before directing into the case. The blower canhave an inlet placed around the circumference of the coil for injectingair, to remove heat from the coil. A connecting tube (not shown) canensure connection of the applicator 5 with the energy source and/orcontrol unit of magnetic stimulation device. The connecting tube mayalso contain a conduit of the fluid.

The arrows 6 indicate the air flow through the applicator 5. Thisarrangement of the blower allows the air to bypass the coil from upperand lower (patient's) side. Outlet may be preferably placed on upperside of the casing. By placing the blower around the circumference ofthe coil instead of on the top/below the coil, the blower 4 does notinterfere with the magnetic flux peak and therefore its lifespan andreliability is increased.

FIG. 3 is an illustrative embodiment of a casing of the magneticapplicator. The overview drawing contains casing itself 7, which mightcontain an outlet 8 preferably placed on upper side of the casing 7. Aconnecting tube 9 may not only ensure connection of the applicator withthe energy source and/or control unit of magnetic stimulation device,but also connection to a source of the fluid; however the conduit of thefluid 10 may also be connected separately.

In an alternative embodiment cooling may be provided by a member usingthermoelectric effect, e.g. a Peltier cooler. Alternatively, cooling maybe provided by Stirling engine cooling system.

FIG. 4A and FIG. 4B illustrate circuits for providing high power pulsesto the stimulating coil. FIG. 4A shows a circuit for providing highpower magnetic pulses. FIG. 4B shows a circuit for providing high powerpulses.

The state of art magnetic stimulation device achieves magnetic fluxdensity of a few tenths to several ones of Tesla (1 Tesla is equivalentto 10000 Gauss). To achieve this level of magnetic flux density, theenergy source used generates sufficient voltage. This voltage can reachthousands of volts. In FIG. 4A the circuits for providing high powerpulses to the stimulating coil contain a series connection to the switch11 and the coil 12. The switch 11 and the coil 12 together are connectedin parallel with an energy storage device 13. The energy storage device13 is charged by the energy source 14 and the energy storage device 13then discharges through the switching device 11 to the coil 12.

During second half-period of LC resonance, the polarity on the energystorage device 13 is reversed in comparison with the energy source 14.In this second half-period, there is a conflict between energy source14, where voltage on positive and negative terminals is typicallythousands of Volts. The energy storage device 13 is also charged to thepositive and negative voltage generally to thousands of Volts. As aresult, there is in the circuit, consequently, twice the voltage of theenergy source 14. Hence the energy source 14 and all parts connected inthe circuit are designed for a high voltage load. Therefore, theprotective resistors and/or protection circuitry 15 must be placedbetween energy source 14 and energy storage device 13. Disadvantage ofstate of art solution is large amount of energy transformed to undesiredheat in protective resistors and/or protection circuitry 15.

FIG. 4B shows a circuit for providing high power pulses for improvedfunction of the magnet stimulation device. The coil 16 and an energystorage device 17 are connected in series and disposed in parallel tothe switch 18. The energy storage device 17 is charged through the coil16. To provide an energy pulse, controlled shorting of energy source 33takes place through the switch 18. In this way the high voltage load atthe terminals of the energy source 19 during the second half-period ofLC resonance associated with known devices is avoided. The voltage onthe terminals of energy source 19 during second half-period of LCresonance is a voltage equal to the voltage drop on the switch 18.

The switch 18 can be any kind of switch such as diode, MOSFET, JFET,IGBT, BJT, thyristor or their combination. Depending on the type ofcomponent the load of energy source 19 is reduced to a few Volts, e.g.,1-10 volts. Consequently, it is not necessary to protect the energysource 19 from a high voltage load, e.g., thousands of Volts. The use ofprotective resistors and/or protection circuits is reduced oreliminated. The present designs simplify the circuits used, increaseefficiency of energy usage and provide higher safety.

FIG. 5 shows an exponential voltage drop in the energy storage device.Energy savings during time-varying magnetic therapy may be characterizedby reduced voltage drop in the energy storage device between the first,second and subsequent maximums of the resonant oscillation. Themagnitude of the individual voltage oscillations is exponentiallydampened up to establishing the energy balance. This allows increasingthe maximum possible frequency/repetition rate of magnetic pulses, sincethe frequency/repetition rate is dependent on the speed with which it ispossible to recharge the energy storage device. Since the energy storagedevice is recharged by the amount of energy loss during the previouspulse, it is possible to increase the frequency/repetition rate of thedevice up to hundreds of magnetic pulses per second without the need toincrease the input power. The voltage drop between any of the successiveamplitudes is not higher than 21%, even more preferably not higher than14% and most preferably not higher than 7%.

The device can be used for treatment/successive treatments in continual,interrupted or various duty cycle regime. The duty cycle may be higherthan 10%, which means interrupted regime with the ratio up to 1 activeto 9 passive time units. The ratio may possibly change during thetherapy. The device enables operation defined by the peak to peakmagnetic flux density on the coil surface at least 3 T, more preferablyat least 2.25 T, most preferably at least 1.5 T at repetition ratesabove 50 Hz, more preferably at repetition rates above 60 Hz, even morepreferably at repetition rates above 70, most preferably at repetitionrates above 80 Hz with treatment/successive treatments lasting severalseconds or longer, for example, for at least 5, 10, 30, 60, 120 or 240seconds, or longer. The total power consumption is below 1.3 kW and thewidth of pulses is in the range of hundreds of μs.

The device enables achieving repetition rates above 100 Hz, morepreferably repetition rates above 150 Hz, most preferably repetitionrates above 200 Hz with the magnetic flux density providing atherapeutic effect on neurons and/or muscle fibers and/or endocrinecells (e.g. at least partial muscle contraction, action potential incell). Based on achievement of repetition rates in order of few hundredsthe device also enables assembling the magnetic pulses into the variousshapes (e.g. triangular, rectangular, exponential), with the shapewidths from 6 ms to several seconds or longer.

Alternatively the magnetic field generating device may generate a staticmagnetic field. The magnetic field generating device generating thestatic magnetic field may be e.g. a permanent magnet or electromagnet.The coil may be powered by a power source, a transformer and/or anenergy storage device. The magnetic field may be applied as time-varyingmagnetic field by movement of the magnetic field generating device.Alternatively the magnetic field generating device may be switched onand off.

During last few decades patient have not only wanted to be in goodhealth, they have also wanted to look well, i.e. to be well shaped,without any unattractive fat and to have a young appearance, withoutwrinkles, stretchmarks or sagging breasts. This has resulted in aprogressive evolution of invasive aesthetic methods such as surgicalremoving of fat and remodeling the human body by invasive andpotentially dangerous methods, e.g. liposuction or inserting implantsinto human body. The side effects of invasive methods may be scars,swelling or bruising. The side effects resulted in the rapid progress innon-invasive method, e.g. lipolysis or removing skin imperfections. Oneexample of the last few years may is rapid increase of patients' demandfor enhancing the visual appearance of buttocks. This has resulted in ahigher percentage of these operations by plastic surgeons.

Electric current may be induced in the treated biological structureduring pulsed magnetic treatment. Due to the high value of magnetic fluxdensity the biological structure may be targeted and treated morespecifically. A distribution of magnetic field is uniform in thebiological structure. Particles (e.g. atoms, ions, molecules etc.) inthe biological structures are influenced by the magnetic field andpermeability of a cell membrane may also increase.

Due to increased permeability of the cell membrane, the pulsed magnetictreatment may induce following effects: at least partial musclecontraction; reduction of adipose tissue—volume and/or number of theadipose cells; neogenesis and/or remodeling of collagen and/or elastinfibers. Further magnetic treatment may improve circulation of bloodand/or lymph and improve local and/or adipose tissue metabolism.

With the present methods, factors for enhancing visual appearance of thebody include: treatment of major muscle, e.g. gluteus maximus; treatmentof deep muscle which may be enabled by high value of magnetic fluxdensity; non-contact application of magnetic flux density, it may beapplied even through clothing; stronger muscle contraction due to highervalue of magnetic flux density; higher-quality of muscle targeting;treatment may not be influenced by small movements during treatment;treatment time duration may be shortened due to high value of magneticflux density and/or higher repetition rate; no delays may occur.

It is to be understood that the method is not limited to the particularapplications and that the method may be practiced or carried out invarious ways.

Present method may be applied for enhancing the visual appearance ofbody parts including or proximate to major muscle structures. Furtherthe method may be applicable for enhancing the visual appearance ofpatients with high value of BMI. A patient with BMI of at least 18,preferably at least 25, more preferably at least 30, most preferably atleast 35 or more may be preferably treated by the recited methods. Thethickness of patient's SWAT and/or VWAT may be at least 0.1, 0.5, 10,15, 25, 50, 75, 100 or more. The patient may be preferably healthywithout any life-threatening conditions such as circulatory systemdisease, e.g. deep vein thrombosis. The present method is not limited tothe application of the treatment to major muscle. Muscles other thanmajor muscles may be treated as well.

The applicator of magnetic treatment may be placed proximate to thepatient's body. As used here, proximate to includes both contactless andin actual contact with the skin of the patient. The muscles may beselectively treated and the magnetic flux density may be adjustedfollowing the patient's feeling or needs. The treatment time may beshortened due to selective treatment of the correct muscles.Additionally, due to the high value of magnetic flux density, the musclemay be treated more effectively. Further, the treatment may benon-invasive or even preferably contactless due to the high value ofmagnetic flux density. The patient may be treated without removingclothing, reducing patient discomfort. Additionally, following the highefficiency of the muscle contraction the collagen and/or elastin fibersabove the muscle structure may be remodeled, hence the visual appearancemay be enhanced.

The position of the patient may correspond to treated biologicalstructure and/or body region. The patient may be treated in seatedposition. Alternatively, the patient may be treated in lying position,e.g. in supine position. Treatment in lateral recumbent position may bealso applicable. Patient may be in prone position as well.

In the preferred application the treatment method may be applied to bodyregions prone to cellulite and/or prone to adipose accumulation, such asthighs, saddlebags, buttocks, abdomen, region of love handles, region ofbra fat or arm. The adipose accumulation may be influenced by numberand/or volume of adipose cells.

The magnetic treatment of the biological structure may have variousapplications for enhancing visual appearance of the contour of a bodyregion. High density magnetic field reaching such values which may beused for: adipose tissue reduction, wherein the adipose tissue reductionmay be achieved by reduction of number and/or volume of adipose cells;muscle toning, wherein the muscle appearance enhancement may be achievedby adipose tissue reduction with no muscle bulking; muscle shaping,wherein the muscle appearance enhancement may be achieved by adiposetissue reduction and/or muscle bulking; body contouring, wherein thesilhouette appearance enhancement may be achieved by adipose tissuereduction with no muscle bulking; body shaping, wherein the silhouetteappearance enhancement may be achieved by adipose tissue reductionand/or muscle bulking; skin tightening, wherein the skin appearanceenhancement may be achieved by obtaining smoother and youngerappearance, including wrinkles reduction; cellulite treatment, whereinthe appearance enhancement may be achieved by adipose tissue reduction,muscle contraction and/or elastic fibers neogenesis; circumferentialreduction, wherein the reduction may be achieved by adipose tissuereduction and/or the muscle bulking; breast enhancement, wherein theappearance enhancement effect may be achieved by elevation or shapemodification; lip enhancement, wherein the lip appearance enhancementmay be achieved by obtaining fuller and firmer appearance. The bodyregion may be reduced in overall size. Further aesthetic effects may beachieved, e.g. connective tissue improvement, fat disruption, musclevolumization, muscle forming, muscle toning, muscle remodeling,contouring, sculpting or body sculpting.

In the methods described, the magnetic stimulation device may or may notinclude a magnetic core. The magnetic stimulation device may be cooledby fluid, e.g. by air, water or oil. Total power consumption of themagnetic stimulation device may be below 1.3 kW. The power of themagnetic stimulation device may be at least 150, 250 or 500 W togenerate a magnetic flux density sufficient to induce at least musclecontraction. A magnetic stimulation device as described in the U.S.patent application Ser. No. 14/789,156 or U.S. patent application Ser.No. 14/789,658, incorporated herein by reference, may be used.

The applicator for magnetic treatment may be placed proximate to thepatient's body. The magnetic flux density may be applied into the targetbiological structure. Electric current may be induced and treat theneuromuscular plate and/or the nerve innervating the at least one musclefiber. The treatment may cause at least a partial muscle contraction.

Furthermore, the present invention discloses the advanced approaches inaesthetic applications, e.g. for cellulite treatment and/or bodyshaping. Combined methods of treatment by electromagnetic field andtreatment by magnetic field are used. The electromagnetic field mayinclude treatment by radiofrequency, infrared or optical waves. Themagnetic treatment may be provided by permanent magnets, electromagneticdevices generating a static magnetic field or time-varying magneticdevices. In the preferred application the treatment by a pulsed magneticfield and radiofrequency treatment may be combined. However theapplication is not limited by the recited combination so the combinedmethod may include magnetic treatment and any treatment byelectromagnetic field, e.g. light treatment, IR treatment or treatmentby radiofrequency waves, e.g. microwaves, short waves or long waves. Themagnetic treatment may also be provided with thermal treatment, e.g.heating and/or cooling.

A device described in U.S. patent application Ser. No. 14/278,756incorporated herein by reference may be used for application of thepresent methods. The device may exclude the balun transformer, or thebalun transformer may be included in transmatch. The possible methods oftreatment by combined methods are described below.

Magnetic treatment in combination with radiofrequency treatment may beapplied by two independent treatment devices, e.g. one device fortreating the biological structure by radiofrequency waves and seconddevice for treating the biological structure by magnetic field. Bothdevices may have a separate applicator for treating the biologicalstructure, or one applicator may be used by at least two devices, i.e.the applicator may be modular for a plurality of devices.

The device may include at least one HF frequency generator for providingenergy for radiofrequency treatment and for providing energy formagnetic treatment. In an alternative embodiment, the device may includeat least one HF frequency generator for providing energy forradiofrequency treatment and at least one other independent frequencygenerator for providing energy for magnetic treatment. The device mayinclude plurality of applicators for providing separate radiofrequencyor magnetic treatments to the patient.

In alternative embodiment the applicator may provide a combination ofradiofrequency and magnetic treatment. In one embodiment, the applicatormay include at least one radiofrequency electrode for providingradiofrequency treatment and at least one magnetic field generatingdevice, e.g. a coil, for providing magnetic treatment. In anotherembodiment, the applicator may include at least one electrode forproviding radiofrequency treatment and at least one magnetic fieldgenerating device providing magnetic treatment, wherein the at least oneRF source provides energy for both at least one electrode and at leastone magnetic field generating device.

In still another embodiment the at least one RF source may provide theenergy for the at least one magnetic field generating device providingmagnetic treatment wherein the at least one magnetic field generatingdevice may be used as the at least one electrode. The essence is the fardifferent stimulation frequencies which are used for RF treatment andmagnetic treatment. The magnetic field generating device in the highfrequency field is similar to the electrode. This enables the magneticfield generating device to be the electrode for radiofrequencytreatment. In the preferred embodiment a flat coil may be used as theelectrode.

The frequencies for the radiofrequency treatment may be in the range ofones of MHz to hundreds of GHz, more preferably in the range of 13 MHzto 3 GHz, most preferably around 13.56 or 40.68 or 27.12 MHz or 2.45GHz. The term “around” should be interpreted as in the range of 5% ofthe recited value. The impulse frequencies for the magnetic treatmentmay be in the range of hundreds of Hz to hundreds of kHz, morepreferably in the range of ones of kHz to tens of kHz, most preferablyup to 10 kHz. However the repetition rate of the magnetic impulses mayreach up to 700 Hz, more preferably up to 500 Hz, most preferably in therange of 1 to 300 Hz, e.g. at least 1, 5, 20, 30, 50, 100, 140 or 180Hz. The magnetic flux density of the magnetic treatment may be at least0.1, 0.8, 1, 1.5, 2, 2.4 or up to 7 Tesla on the coil surface(equivalent to 70000 Gauss). The treatment/successive treatments maylast several seconds, e.g. at least 5, 10, 30, 60, 120 or 240 seconds,or longer, e.g. at least 20, 30, 45, 60 minutes. The impulse durationmay be in the range of 3 μs to 10 ms or more, or alternatively 3 μs to 3ms or alternatively 3 μs to 1 ms. The impulse duration may be e.g. 3,10, 50, 200, 300, 400, 500, 625, 1000, 2000 or 3000 μs. The duty cycleof the stimulation may be at least 1:50, more preferably at least 1:40,even more preferably at least 1:20, most preferably at least 1:8 or upto 1:4. The magnetic stimulation device may emit no radiation.

A derivative of the magnetic flux density is defined by Equation 4.

$\begin{matrix}{\frac{dB}{dt},} & {{Eq}.4}\end{matrix}$

where: dB is magnetic flux density derivative [T]; dt is time derivative[s].

The maximal value of the magnetic flux density derivative may be up to 5MT/s, preferably in the ranges of 0.3 to 800 kT/s, 0.5 to 400 kT/s, 1 to300 kT/s, 1.5 to 250 kT/s, 2 to 200 kT/s, 2.5 to 150 kT/s. In exemplaryapplications the maximal value of the magnetic flux density derivativemay be at least 0.3, 0.5, 1, 2.5, 3.2, 5, 8, 10, 17, 30 or 60 kT/s. Thevalue of magnetic flux density derivative may correspond to inducedcurrent within the tissue.

The magnetic flux density derivative may be determined within the entireperiod of the magnetic signal and/or in any segment of the magneticsignal.

Alternatively the treatment device may include no deep muscle diathermydevice for heating the target biological structure. The treatmentpreferably may include no electrode which may enable heating thebiological structure in contact mode.

Cellulite is an effect of skin change resulting in orange peelappearance. The cause of the cellulite is orientation of collagen fibersin so called “fibrous” septae. The fibrous septae contract and hardenover time creating a dimple effect. Additionally, blood and lymphaticvessels lack circulation due to the contraction and hardening of theseptae. The lymph flow may be blocked resulting in swelling. Anothercause of cellulite may be adipose cells protruding to dermis. Cellulitemay be treated by the recited methods.

One application of time-varying magnetic field for enhancing the visualappearance of body region may be treatment of a muscle by magnetic fluxdensity for reducing the cellulite. The magnetic flux density may bedelivered through the skin to the neuromuscular plate and/or nerveinnervating at least one muscle fiber. The electric current may beinduced in the target biological structure causing at least partialmuscle contraction. The at least partial muscle contraction may causethe movement of the skin and all the biological structures subtendingepidermis. Additionally, the at least partial muscle contraction mayimprove blood circulation by itself, or via the movement of the musclein the vicinity including fibrous septae. Additionally, blood and/orlymph circulation may be improved in the layers subtending epidermissince the muscle contraction may move the fibrous septae. Also localand/or adipose tissue metabolism may be improved.

The lymph flow may be improved by at least partial muscle contractionwhich may provide effect similar to manual massage. The improved lymphflow may improve local metabolism and/or immune system. The improvedlymph flow may contribute to purer lymph due to faster delivery of thelymph to the lymph nodes where the lymph may be cleared.

The present method may provide a massage effect via the treatment whichmay be caused by the at least partial muscle contraction. Therefore themassage effect may be achieved by contactless methods instead of manualmassage techniques or soft tissue techniques. The massage effect mayimprove lymph circulation.

In another aspect, improvement of functionality and/or the appearance ofthe muscle may be achieved with results similar to body exercise. Theresults may be achieved by application of high magnetic flux density tothe body region and inducing at least partial muscle contraction. Highervalues of magnetic flux density applied may result in a stronger musclecontraction. The patient may feel firmer and tighter.

With the present method muscle contractions induced by the appliedmagnetic flux density may help to tone the muscle providing a moreattractive appearance. As the muscle structure is treated bytime-varying magnetic field the entire limb may be moved due to the highpower of the magnetic treatment. Nevertheless, the method is not limitedto the applications to the limbs and the method is able to treat anymuscle, e.g. gluteus maximus or any muscle/deep muscle to induce bodycontouring and/or body shaping effect and fat burn. Additionally,shortened and/or flabby muscles may be stretched. The physical fitnessof the patient may be improved as well.

The magnetic field may treat various body regions, e.g. thighs,buttocks, hips, abdomen or arms. The muscles may be shaped to enhancevisual appearance of the treated body region. The body part may obtainenhanced visual appearance of its contour.

The magnetic field may treat at least one muscle of lower limb,particularly the parts which are prone to cellulite such as thighs orsaddlebags. The time-varying magnetic field may induce at least partialmuscle contraction in different muscle and/or muscle group. Followingthe position and/or orientation of the magnetic field generating devicethe anterior, posterior and/or medial compartment of the thigh may betreated. The anterior compartment includes sartorius muscle, rectusfemoris muscle, vastus lateralis muscle, vastus intermedius muscle,vastus medialis muscle. Posterior compartment includes biceps femorismuscle, semitendinosus muscle and semimembranosus muscle. Medialcompartment includes pectineus muscle, external obturator muscle,gracilis muscle, adductor longus muscle, adductor brevis muscle andadductor magnus muscle.

The treatment may cause circumferential reduction of thighs. Further themuscle may obtain enhanced visual appearance, thigh may be well-shaped.Thigh contour may be enhanced as well.

The at least one surrounding body region may be treated as well, e.g.buttocks.

The applicator may be placed within proximity of the patient's treatedarea. The applicator may be fixed to the patient. Alternatively thecorrect position may be provided by a mechanical arm and/or adjustableapplicator. The applicator may be made of adhesive and/or high frictionmaterial at least on contact surface with the patient.

The magnetic field may be generated with a low repetition rate such as 1Hz for a predetermined period of time, e.g. 30 seconds, sufficient forsetting the applicator to a correct position where the treatment is mosteffective. During the period the magnetic flux density may be adjustedfollowing the patient's needs to induce muscle contraction sufficientlystrong and comfortable for the patient.

The treatment may start a treatment protocol. The treatment protocol mayinclude a set of predetermined treatment sequences of predeterminedrepetition rates applied for predetermined time periods. The sequencesmay be repeated and/or adjusted following the patient's need. Thesequence may include a repetition rate in the range of 1 to 100 Hz,preferably in the range of 2 to 90 Hz, more preferably in the range of 5to 50 Hz, most preferably in the range of 10 to 45 Hz. The sequences maylast at least 30, 45, 60, 90, 120 or up to 300 seconds.

Alternatively the treatment may include the only the treatment protocolwithout applying the magnetic field of low repetition rate. The correctposition of the applicator and/or adjusting the magnetic flux densitymay be adjusted during the first sequence of the treatment protocol.

In one application, the treatment may induce the same effect as muscleexercising of buttocks. During the treatment of buttocks the magneticfield may be targeted to treat of muscles shaping the buttocks, e.g.tensor fasciae latae muscle or at least one of gluteal muscles: maximus,medius or minimus. In one preferred application all three glutealmuscles may be treated. Further other muscles may be treated, e.g.abdominal muscles, spinal muscles and/or thoracic muscles. By thecomplex treatment and muscle contraction in the body region the treatedmuscles may be strengthened, toned, the cellulite may be reduced anddimples may be removed. Buttocks and even the patient's figure may beenhanced in visual shape appearance and may become more attractive.Buttocks become well-shaped, round, firm, well-trained, toned, smoother,tight and lifted. The complex treatment may reduce hips, make perfectround and lifted buttocks, increasing the self-confidence of the patient

The treatment may be more efficient than standard workout in fitnesssince the fitness machines strengthen only the isolated muscles. Theresults may be achieved in very short-time periods with minimal time oftreatment. Without being limited, it is believed that the exercising ofthe gluteus medius may reduce the volume of the buttocks; exercising ofthe gluteus maximus may shape and/or lift the buttocks; exercising ofthe gluteus minimus may lift the buttocks.

In the preferred application the magnetic treatment may be combined withother treatment methods using different approaches, e.g. conventionalnon-invasive treatments. The combined treatment may be applied to thesurroundings tissues around buttocks to reduce the cellulite around thebuttocks and enhance the shape of the enhanced appearance of thebuttocks. The surrounding tissues may be represented by e.g. abdomen,love handles, thighs or saddle bags.

The magnetic field may treat at least one muscle responsible forsilhouette of the body. The time-varying magnetic field may induce atleast partial muscle contraction in different muscle and/or muscle groupresponsible for silhouette in the region of abdomen, love handles and/orbra fat. Following the position and/or orientation of the magnetic fieldgenerating device rectus abdominis muscle may be treated. Alternativelylatissimus dorsi muscle, abdominal internal oblique muscle, abdominalexternal oblique muscle, transverse abdominal muscle and/or pyramidalismuscle may be treated by the time-varying magnetic field.

The treatment may cause circumferential reduction in the region ofbelly, hips and/or love handles. Alternatively the treatment may tightenat least one of these body parts. Further the muscles may obtainenhanced visual appearance, belly may be well-shaped. Repetitiveapplication may even reach in a six-pack look. The at least onesurrounding body region may be treated as well, e.g. buttocks.

The magnetic field may treat at least one muscle of upper limb,particularly the parts which may be prone to cellulite such as arm. Thetime-varying magnetic field may induce at least partial musclecontraction. Following the position and/or orientation of the magneticfield generating device the at least partial muscle contraction mayoccur in biceps brachii muscle, brachialis muscle, coracobrachialismuscle and/or triceps brachii muscle.

The treatment may cause circumferential reduction of the arm. Furtherthe muscle may obtain enhanced visual appearance, arm may bewell-shaped. Arm contour may be enhanced as well.

The at least partial muscle contraction may be more efficient foradipose tissue metabolism as the value of magnetic flux densityincreases since the muscle contraction may be stronger. The highermagnetic flux density may treat the higher number of muscle fiberscontraction and the more adipose tissue may be reduced. Therefore thevisual appearance of regions prone to cellulite may be enhanced.

Treatment by time-varying magnetic field may induce lipolysis. Adiposetissue may be reduced by decreasing the number and/or volume of adiposecells. Promoted adipose cell metabolism may increase as the value ofmagnetic flux density increases. The treatment may release free fattyacids (FFA) from at least one adipose cell. The increased concentrationof FFA may influence a homeostasis of the adipose cell. A disruption ofthe homeostasis may cause a dysfunction of the adipose cell. Thedysfunction may be followed by stress for endoplasmic reticulum (ERstress). ER stress may cause additional lipolysis and/or apoptosis ofthe at least one adipose cell.

Furthermore, ER stress may cause increase of intracellular calcium ions(Ca2+) which may promote an apoptotic process and may continue intocontrolled cell death of the adipose cell. The apoptosis may be inducedby Ca-dependent effectors, e.g. calpain or caspase-12. Endogenousligands or pharmacological agents, such as vitamin D, may induceprolonged cytosolic calcium increase. Vitamin D may influence release ofCa2+ from endoplasmic reticulum. Hence the effect of treatment may beenhanced by application of vitamin D and/or Ca2+ prior, during and/orafter the treatment. The most significant effect may be achieved byapplication of both, Ca2+ and vitamin D, prior the treatment to provideall factors influencing adipose cell apoptosis.

Alternatively, increased level of Ca2+ may induce autophagy withinadipose cell as well. Autophagy is self-eating process of cellularorganelles to produce energy and it may proceed into cell death.Autophagy may be induced by ER stress or it may be induced via Ca2+signaling.

FIG. 6 illustrates pathways which may induce apoptosis of the at leastone adipose cell. FFA may accumulate in the at least one adipose cell(20). The magnetic field may induce lipolysis (21), i.e. a release ofFFA from adipose tissue. Accumulated FFA may reach a threshold whenadipose cell is unable to utilize FFA. A dysfunction of the adipose cellmay occur. The adipose cell may react on the dysfunction by ER stress(22). ER stress may induce lipolysis hence additional release of FFA mayoccur (20). ER stress may cause apoptosis of the adipose cell (23).Furthermore, the ER stress may release Ca2+ (24) which may contributethe apoptosis (23).

The effect of the treatment by magnetic field for adipose tissuereduction may be influenced by various biological processes and/orpathways as recited above. The processes and/or pathways may be synergichence the adipose tissue reduction may be accelerated and/or moreefficient.

The method may cause the circumferential reduction i.e. a reduction ofthe size of the treated body region. The method may be mostly indicatedfor the regions with cellulite, particularly for thighs, buttocks,saddlebags, love handles, abdomen, hips and/or arms. However, theindication is not limited to the mentioned regions and the method may beused for treatment of any other body region.

Furthermore, the method may change BMI index of the patient. In apreferred application the BMI of the patient may be reduced.Alternatively, the BMI of the patient may increase.

Heating/Cooling

The magnetic field may be combined with application of heat and/or cold.The body region may be heated/cooled. The target biological structuresmay be selectively treated due to different tolerance of variousbiological structures to heating/cooling. Applying of heat/cold mayimprove metabolism of the biological structure, alternatively areduction of the biological structure may occur.

Various biological structures have a different tolerance toheating/cooling. Hence target biological structures may be remodeled,e.g. adipose cells may be selectively reduced. The cells different fromadipose cells such as epidermal cells, are not reduced by theheating/cooling. The selective reduction of adipose cell may be causedby e.g. crystallization within adipose cells. The heating/cooling of theadipose cell may reduce the number and/or volume of adipose cells bylipolysis, apoptosis and/or necrosis.

Cooling

Although the following exemplary treatment describes applying cold tothe patient, the treatment method is not limited to the exemplaryapplication. The method may include heating the patient instead ofcooling the patient.

The cooling may be provided in a contact, indirect contact and/ornon-contact manner. Contact cooling may be provided by a cooling elementplaced to the proximity of the treated body region, e.g. a thermallyconductive material such as metal, gel or ice may be used. Indirectcontact may be provided by a flow of cooling media within a layer offlexible and/or rigid material, e.g. cooling media such as glycerol,saline or water solution may be used. The cooling element may include aplurality of passages which the cooling media may flow in. Non-contactcooling may be provided by radiant cooling. Alternatively cooling mediamay be applied directly on the body region. The cooling media used fornon-contact heating/cooling may be preferably a fluid, e.g. a gas orliquid. The gas may be applied in form of a spray, e.g. cold air, CO2 orN2 may be used. The cooling media may be at a predetermined temperaturewhich may be controlled by the device to induce selective treatment ofthe target biological structure.

In an exemplary application the adipose cells may be selectively treatedby cooling. A cooling media may be applied to the body region. Areduction of adipose cell may be induced by cooling the adipose cell.The cells different from adipose cells are not reduced by the cooling.

Temperature Ranges

The temperature of the cooling media and/or element may be less than thetemperature of the patient's body. The temperature of cooling media maybe at least −196° C. The temperature of the cooling element may bepreferably in the range of 40 to −40° C., more preferably in the rangeof 20 to −20° C., even more preferably in the range of 10 to −15° C. orin the range of 5 to −10° C. A temperature of the adipose cells may beabove a freezing point of water to prevent a reduction of cellsincluding water. The temperature of the adipose cells may be preferablyin the range of 37 to −10° C., more preferably in the range of 20 to −4°C., even more preferably in the range of 15 to −2° C. or around 4° C.The temperature of epidermis may be at least −40, −20, —10, 15, 20, 35°C., more preferably the temperature of epidermis may be in the range ofaround 5 to −5° C. The term around may be interpreted to mean in therange of 10% of the particular value.

Alternatively the body may be heated by application of various treatmentmethods, e.g. radiofrequency, diathermy or optical waves. Thetemperature in the target tissue may be up to 80° C., more preferably inthe range of 37 to 60° C., even more preferably in the range of 39 to50° C., most preferably in the range of 42 to 47° C. The temperature maybe adjusted based on the intended use, e.g. adipose tissue reduction orcollagen production.

The temperature of adipose cells may vary during the treatment. Thetemperature of the adipose cells may oscillate around a predeterminedtemperature. The temperature of the adipose cells may also follow atemperature profile in a predefined temperature range. The temperatureand/or the temperature range may be adjusted following the patient'sneeds.

Cycles

Alternatively the adipose cells may be heated prior, during and/or aftercooling. The term “heat prior” refers to preheating the adipose cellsbefore cooling treatment. The term “heat during” refers to cyclicallychanging periods of cooling and heating the adipose cells during thetreatment. The treatment may also include passive periods betweenheating and/or cooling. The term “passive period” refers to applyingneither heating nor cooling. The term “heat after” refers to applyingheat after the cooling treatment. The periods of heating/cooling and/orpassive periods may be adjusted following by the patient's need.

Treatment Duration

The cooling may be applied for at least 10 seconds. Time duration ofcooling the body region may be in the range of 1 to 240 minutes, morepreferably in the range of 5 to 120 minutes, even more preferably 10 to60 minutes, most preferably up to 30 minutes.

The cooling element and/or media may be applied continuously and/or inpulses. Continuous application may be used for a cooling element and/ormedia at a temperature above 0° C. Pulsed mode may be used forapplication of fluids below 0° C. The cooling may be provided cyclicallyfor short periods in order of milliseconds, e.g. N2 may be appliedcyclically to prevent damage to epidermis/dermis. The cooling elementand/or media may be applied preferably non-invasively, e.g. by topicalapplication. Alternatively the cooling element and/or media may beapplied subcutaneously, e.g. injected.

Adjustable Applicator

The cooling element may correspond with the body region. The coolingelement may be adjustable in shape to fit the body region. The coolingelement may be made of flexible material to be modified in shape tofollow the shape and/or contour of the body region. A fitting of thecooling element may provide homogenous treatment and/or temperaturedistribution. Further the heat exchange may be optimized at thecontacted surface.

Pressure

A treatment may induce a thermal gradient in the body region, i.e. theshallow layer of the skin such as epidermis and/or dermis may have alower temperature than the deeper layer such as adipose tissue. Theeffect of cooling may be improved by limiting and/or eliminating dermalblood flow. The dermal blood flow may be limited by applyingvasoconstrictive medicine, preferably topically administered.

Positive

The dermal blood flow may also be limited and/or eliminated by applyinga pressure. The pressure greater than systolic blood pressure may beused for pushing the blood out of the dermal and/or subcutaneous veins.The deeper adipose cells may be cooled and/or the cooling of the adiposecells to the temperature sufficient to reducing the adipose cells may bereached in shorter time period. Furthermore appropriate contact of thecooling element may be provided by the pressure in case of contacttreatment.

Negative

The treatment effect may also be enhanced by applying negative pressureto the skin below the applicator, e.g. a convex cooling element may beused. The skin may be pulled towards the inner surface of the coolingelement. Hence the contact may be enabled by applying negative pressure.Alternatively, the folded tissue may be pinched by two or more coolingelements and the cooling may be applied to the tissue, particularly toadipose cells. Further the skin may be stretched and a thickness of theskin may decrease. Skin thickness decrease may promote improved heattransfer to/from adipose cells.

Miscellaneous

The cooling may be applied with application mechanical treatment such asacoustic, ultrasound, and/or shockwave treatment to enable morehomogenous treatment effect. The adipose cells reduction may also bepromoted by physical movement of the body region by e.g. massaging, orvibrations. The pressure applied to the body region may vary to improvethe results.

Protocols

An apoptotic index may increase after cooling the body region. Theapoptotic index refers to a percentage of apoptotic cells in specimen.The apoptotic index may increase due to cooling up to ten times greatervalue compared with the value prior the cooling.

Based on the apoptotic index a treatment combining various methods maybe designed as a tailor-made solution following the patient's need. Thecooling may be applied to the body region of the patient prior, duringand/or after applying a magnetic field to the patient.

Pain Relief

A pain relieving medicament may be provided during the treatment if thepatient is more sensitive to decreased temperature. A topicalapplication may be preferred. The pain relief effect may be provided bya magnetic field of repetition rate at least 100 Hz, more preferably 120Hz, even more preferably at least 140 Hz or at least 180 Hz. The painrelieving effect may be provided before, during or after the treatment.

Precooling

Cooling the body region prior to applying the magnetic field mayinfluence a metabolism of adipose cells. Alternatively, the cooling ofthe adipose cells may induce apoptosis, lipolysis, autophagy and/ordisruption of the adipose cells. A release of FFA from adipose cells mayinduce ER stress as recited above. The application of the magnetic fieldmay cause at least partial muscle contraction reducing the adiposecells. Furthermore the released FFA from adipose cells influenced bycooling may be used as energy source for muscle work. Hence the coolingmay be followed by treating a patient by magnetic field inducing atleast partial muscle contraction. Due to the combined effect of coolingand magnetic treatment the adipose cells may be reduced in number and/orvolume. Moreover the muscles may be shaped, tightened, strengthenedand/or the volume of the muscle may increase. Additionally, thecellulite appearance may be reduced due to muscle work.

The magnetic treatment may provide a massage effect. Hence blood and/orlymph flow may be improved. Additionally frozen tissue may be relaxed.

The combined magnetic treatment may be applied immediately aftercooling, more preferably around 1 to 24 hours after cooling, e.g. 1, 2,8 or 20 hours after cooling. The combined treatment may be appliedperiodically. Alternatively, the treatment by cooling and/or magneticfield may be applied separately, e.g. treatments may alternate inappropriate periods. The period may last from 12 hours to 1 month, morepreferably from 1 day to 2 weeks, most preferably from 3 days to 1 week.

In an exemplary application of the treatment method a patient's bodyregion may be cooled by a cooling element for e.g. at least 20 minutesup to 1 hour. After stopping the cooling the body region may be treatedby magnetic field for e.g. 15 to 45 minutes.

Cooling

Cooling the body region may be applied simultaneously while the bodyregion is treated by magnetic field within one treatment.

The magnetic cooling may be provided to the patient while the patient isbeing treated by magnetic field.

Alternatively, cooling may alternate with treatment by magnetic field,i.e. the magnetic field is applied when cooling is not provided to thepatient or vice versa. Periods of alternating cooling and magnetictreatment may vary.

The magnetic field may be preferably applied in burst mode. Each burstcontains train of magnetic impulses and a period of no magnetictreatment. The train may include a plurality of magnetic impulses. Anumber of magnetic impulses may vary in the range of at least 1 to 10000impulses, more preferably in the range of at least 10 to 1000 impulses.The time duration of the train and/or the period of no magnetictreatment may vary in order of milliseconds to order of seconds, e.g. inthe range of 100 milliseconds to 100 seconds, more preferably in therange of 1 to 30 seconds, most preferably in the range of 5 to 15seconds.

In one exemplary application the body region may be cooled for a periodof e.g. at least 5 minutes. After stopping the cooling the body regionmay be treated by a magnetic field for a period of e.g. at least 5minutes. After stopping the magnetic treatment the body region may becooled.

Post Cooling

The cooling may also be applied after magnetic treatment. The treatmentby magnetic field may provide stimulation, pain relief and/or amyorelaxation effect for the treated body area before cooling. Thecooling applied with pressure may be better accepted by the adiposetissue when the muscle below the adipose cells is relaxed. Alternativelythe magnetic treatment may provide a temporary pain relief effect hencea patient suffering from a lower pain threshold, e.g. cool sensitivity,may be treated.

In an exemplary application the body region may be treated by a magneticfield for a period of e.g. at least 15, 20 or 30 minutes. After stoppingthe magnetic treatment the body region may be cooled.

The cooling may be applied immediately after magnetic treatment, morepreferably around 1 to 24 hours after magnetic treatment, e.g. 1, 2, 8or 20 hours after magnetic treatment. The combined treatment may beapplied periodically.

In an exemplary application of the treatment method a patient's bodyregion may be treated by magnetic field for e.g. at least 20 minutes upto 1 hour. After stopping the magnetic treatment the body region may betreated by cooling for e.g. 15 to 45 minutes.

In the previously described exemplary treatment methods the cooling ofthe patient may be replaced by heating the patient.

FIGS. 7A and 7B illustrate an application of the treatment by a deviceproviding heating/cooling to the body region of the patient 25. FIG. 7Aillustrates a treatment device 26 including a connection to powersource, a magnetic field generating device 27 and means for providingheating/cooling 28, e.g. RF source or cooling element. FIG. 7Billustrates alternative treatment applied by two separate treatmentdevices, i.e. by a device providing magnetic treatment 29 and a deviceproviding heating/cooling 30.

All the recited combined treatment methods may be provided by at leastone applicator. The applicator may provide cooling and magnetictreatment. Alternatively one applicator may provide cooling and secondapplicator may provide magnetic treatment.

The target structure may be treated by combined methods which may beused for remodeling the adipose tissue, body shaping and/or contouring,muscle toning, skin tightening, skin rejuvenation, wrinkle removing,reducing stretchmarks, breast lifting, lip enhancement or treatment ofcellulite in general by application of electromagnetic radiation totarget structure to selectively heat the target tissue to remove and/orremodel adipose tissue from the target tissue. The second approach is totransmit a magnetic treatment to the target structure, inducing at leastpartial muscle contraction within the target structure to remodel theadipose tissue by natural adipose tissue catabolism. Adipose tissuecatabolism may be caused by apoptosis or necrosis of the adipocytes. Themuscle contraction caused by induced eddy current is the same as anatural contraction. The adipose tissue may be reduced in natural way.Additionally, the muscle may be shredded in a natural way. Therefore theeffect resulting in body shaping and/or contouring may be significantlyimproved.

The combination of the recited method may improve currently usedapplications in various aspects and the effect of the treatments may besignificantly enhanced. The application of a radiofrequencyelectromagnetic field may be combined with application of a magneticfield applied before, simultaneously or after the radiofrequencytreatment. The application of a magnetic field may induce many benefitsfor radiofrequency treatment, such as applications inducing at leastpartial muscle contraction, myorelaxation effect or analgesic effect.The perfusion or metabolism may be improved as well.

The at least partial muscle contraction may induce enhanced effects onadipose tissue reduction by catabolism of the adipose tissue and burningenergy from adipose tissue. The total adipose tissue reduction effectmay be enhanced by radiofrequency treatment.

Additionally, the at least partial muscle contraction may improve ablood flow and/or perfusion in the treated body region. The improvedblood flow may be caused by activation of muscle pump and/or by themuscle necessity of more oxygen due to the at least partial contraction.The blood flow may increase rapidly and it may last temporarily,preferably up to 1 hour, more preferably up to 45 minutes, mostpreferably up to 30 minutes. Due to increased blood flow and/or localperfusion, the risk of overheated muscle may be limited or eveneliminated. Further the homogeneity of the thermal field induced bythermal effect of radiofrequency treatment may be significantly enhancedand/or the temperatures may be well-balanced/compensated in the targetbody region. Still another benefit may be prevention of creation any hotspot caused by steep thermal gradient.

Due to improved blood flow, perfusion and/or lymph flow the metabolismmay be improved. Additionally, the effect of radiofrequency treatmentmay be enhanced by improved metabolism, e.g. cellulite treatment, bodyshaping and/or contouring, skin tightening or skin rejuvenation. Furtherbenefit may be reducing or eliminating the risk of panniculitis or localskin inflammation since any clustering of the treated adipocytes may beprevented by the improved metabolism. The improved blood and/or lymphflow may contribute the removing of the adipocytes. The removing of theadipocytes may be promoted by higher number of cells phagocytosing theadipocytes as well. Synergic effects of magnetic and RF treatment maysignificantly improve metabolism. Therefore the possibility of adverseevent occurrence may be limited and treatment results induced by thepresent invention may be reached in shorter time period.

Further the at least partial muscle contraction may improve the movementof lymphatic vessel and the lymph flow may be improved.

In the preferred application the RF and/or magnetic field may bemodulated. In the most preferred application both treatments aremodulated. The magnetic treatment may be modulated in the magnetic fluxdensity domain, repetition rate domain, or impulse duration domain, toprovide different treatment effects and to prevent adaptation of thetarget biological structure. The radiofrequency treatment may bemodulated in the frequency domain, intensity domain and/or time domainto reach the most complexity and/or efficiency of the target treatedbiological structure. The modulation in the time domain may be changingthe active and passive periods of stimulation, e.g. the radiofrequencytreatment may include period with no stimulation, i.e. theradiofrequency treatment may be not continual but the treatment may beprovided in pulses. The periods of no stimulation may vary and may beadjusted by the operator. Due to modulation during the treatment,different target biological structures may be treated in the differentdepth.

The application may be contact or in the preferred application thetreatment may be applied contactless. Contactless application may avoidall biocompatibility factors which may occur during contact treatment.In the most preferred application the treatment may be provided byself-operated device. Hence the applicator and/or magnetic fieldgenerating device need not be guided by the operator. The applicator maybe fixed at a sufficient distance from the patient's skin enabling safetreatment for the patient. Self-operated treatment may be provided by ahand-held applicator or the applicator may be fixed to stand-alonedevice. The self-operated treatment may be also enabled using varioustypes of sensors in communication with the device for monitoring thetreatment and/or the patient. The at least one sensor may be e.g.reactive sensor, electrochemical sensor, biosensor, biochemical sensor,temperature sensor, sorption sensor, pH sensor, voltage sensor, sensorfor measuring distance of applicator from the patient surface and/orfrom the treated area, position sensor, motion detector, photo sensor,camera, sound detector, current sensor, sensor for measuring of specifichuman/animal tissue and/or any suitable sensors measuring biologicalparameters and/or combination thereof such as sensor for measuringdermal tensile forces, sensor for measuring the activity of the muscle,muscle contraction forces, tissue impedance or skin elasticity.

Further the homogeneity of the treatment may be improved by severalapproaches. A first approach may be represented by a moveable applicatorproviding the dynamic treatment to a large target area. The dynamictreatment may improve the homogeneity of applied treatment energy andadditionally due to large area the effect is uniform and/or wellbalanced. Static positioning of the applicator may be used as well.Another approach of improving homogeneity may be represented by using abolus. The bolus may provide improved transmittance of theelectromagnetic energy to the treated biological structures.Additionally, the bolus may prevent occurrence of hot spots within thetreated area; the bolus may provide constant temperature to the targettreated surface area; or the bolus may increase the homogeneity of theradiofrequency waves application by providing a homogenous medium forelectromagnetic waves propagation not being influenced by the interfaceof the target treated area and an air. The bolus may profile theelectromagnetic field to enhance the effect of the treatment. In stillanother approach an air gap may be between the applicator and thepatient.

The treatment by magnetic and/or electromagnetic field may be incontinuous or discrete mode. In one application the magnetic treatmentmay be applied in continual mode with no pauses and the electromagnetictreatment may be applied in pulsed mode to provide improved adiposetissue reduction caused by natural process and by the increasedtemperature. In another application the electromagnetic treatment may beapplied continuously with no pauses and the magnetic treatment may beapplied in pulsed mode to provide improved thermal reduction of adiposetissue and by improved metabolism due to improved blood flow. Both modesmay be combined in various treatment sequences.

In the preferred application the treatment may be started at the momentwhen the target biological structure reaches the predeterminedtemperature. The temperature in the target tissue may be up to 80° C.,more preferably in the range of 37 to 60° C., even more preferably inthe range of 40 to 45° C. The temperature may be adjusted based on theintended use, e.g. adipose tissue reduction, collagen production ormuscle contraction. In an alternative application the intended use maybe coagulation and/or ablation. The temperature in the target biologicalstructure may be measured by invasive method, e.g. using an invasiveprobe; or by contact method, e.g. using thermocouple sensor; or bycontactless method, e.g. using infrared sensor or camera. Thetemperature of the target biological structure may be determined by amathematic method. The sensor for measuring the temperature in thetarget biological structure may be attached to the applicator.

A benefit of the application of magnetic treatment and electromagnetictreatment may be causing an analgesic effect of the application andproviding a possibility of treating a patient with higher sensitivityfor thermal effects induced by electromagnetic treatment, i.e. patientswith any predisposition inducing increased thermal sensitivity. Theanalgesic effect may be induced by magnetic treatment by suitablerepetition rates and it may be induced immediately during the magnetictreatment. The analgesic effect may last up to several hours aftermagnetic treatment. The magnetic flux density of the magnetic treatmentmay preferably reach at least motor-threshold intensity inducing atleast partial muscle contraction therefore the homogeneity of thethermal field may be significantly enhanced.

Another benefit of application the magnetic treatment may be causing amyorelaxation effect. The magnetic treatment may be applied on spasticmuscle structures to relieve the hypertonus of the muscle and improvingthe blood and/or lymph flow. Therefore relieving the hypertoned musclemay contribute to the analgesic effect and contribute to theacceptability of the treatment by the patient.

The blood and/or lymph flow may be limited in the spastic muscles andthe metabolism may be limited as well, meaning that the risk ofclustering the treated target structures may be higher and possibleadverse events may occur. The recited risks may be eliminated by theused of magnetic treatment.

In one aspect of the invention, the treatment by magnetic field may beapplied to the target structure before the radiofrequency treatment toprepare the target structure for following treatment by radiofrequencyfield. The effect of magnetic treatment may be to induce at leastpartial muscle contraction or to treat a muscle structure to increase amuscular tonus of the target structure. Both effects may provide amassage effect for the structure within the proximity of the targetstructure hence the blood and/or lymph circulation may be improved topromote local metabolism. The temperature may be locally increased bythe improved blood flow and the target structure may accept thefollowing radiofrequency treatment at significantly higher quality.Additionally, the collagen and/or elastin fibers may be remodeled orrestored and/or its neogenesis may be improved to provide a younger,smoother, firmer and enhanced skin appearance.

Additionally, previous application may improve acceptability of theelectromagnetic field by increasing the temperature of the skin and thetransmittance of the electromagnetic field may be improved due to lessvalue of skin impedance. Further the radiofrequency may penetrate deepertarget structures relative to treatment without a preceding magnetictreatment of the target structure and/or area.

Another benefit may be releasing the adipose tissue in the muscle bymuscle contraction and/or by temperature increase causing betterliquidity of adipose tissue. Still another benefit of the at leastpartial muscle contraction may be mechanical breaking large adiposetissue bulks into smaller bulks which may be easier metabolized and/orthe smaller adipose tissue bulks may be removed faster by the lymphaticand/or blood flow. Due to improved metabolism and/or circulation thecellulite may be treated in a short time and the visual effect on skinappearance may be significantly enhanced.

In another aspect of the invention, the treatment by magnetic field maybe applied to the target structure simultaneously with theradiofrequency treatment to improve effects of the electromagnetictreatment inducing heat in the target structure.

The simultaneous application of magnetic treatment and radiofrequencytreatment may be in two modes: a first mode may generate the magneticimpulses while radiofrequency treatment is active or another mode maygenerate radiofrequency treatment while the magnetic treatment is not inan active stimulation period, i.e. the period of magnetic treatment andradiofrequency treatment alternates. Both modes amplify the resultingeffect of the treatment. Therefore the results may be achieved insignificantly shorter time than the same results achieved by separateapplications of the radio frequency and magnetic treatments.

The simultaneous method of magnetic treatment and radiofrequencytreatment of the target tissue may increase the peak magnetic componentof the entire treatment resulting in improved heating of the targetstructure including containing higher water volume, e.g. skin. Due toincreased temperature of skin, the production and/or remodeling ofcollagen and/or elastin fibers may be improved and the skin may beprovided with a younger, smoother, firmer and enhanced appearance. Theeffect of overheating the muscle may be reduced by the improved bloodflow.

In still another aspect of the invention, the treatment by magneticfield may be applied to the target structure after the treatment byelectromagnetic field to enhance and/or contribute to the effects ofradiofrequency treatment by influencing the target structure by magneticfield.

The magnetic field may treat the target structure to cause at leastpartial muscle contraction proximate to the target structure to improveblood flow and provide homogenous temperature distribution at highquality after creating a temperature distribution at lower quality byradiofrequency treatment.

All of the methods may be provided by the above recited technicalsolutions. The above mentioned methods may be used separately or in anycombination.

The method may cause the circumferential reduction i.e. a reduction ofthe size of the treated body region. The method may be mostly indicatedfor the regions with cellulite, especially for buttocks, saddlebags,love handles, abdomen, hips, thighs or arms. However, the indication isnot limited to the mentioned regions and the method may be used fortreatment of any other body region.

The at least one applicator may include at least one magnetic fieldgenerating device. The plurality of magnetic field generating devicesmay be positioned in isolated locations of the at least one applicator.Alternatively, the magnetic field generating devices may be positionednext to each other, in an array or matrix, in a pattern or in randomizedlocations of the at least applicator.

The magnetic field generating devices may be positioned and/or moved inthe at least one applicator in one plane; in at least two mutuallytilted planes defined by a convex or concave angle, or perpendicular toeach other; or in at least two parallel planes with the at least onemagnetic field generating device in each parallel plane. The movement ofthe at least one magnetic field generating device may be translationaland/or rotational, constant or accelerated. The movement may follow apredetermined, random or predefined trajectory, such as a pattern, arrayor matrix. The movement of the at least one applicator may be handled insimilar manner as the movement of the at least one magnetic fieldgenerating device. The angles of the planes and/or the movement of theat least one magnetic field generating device may be adjusted by anoperator following the patient's needs. The positioning may be providedby mechanical holder, enabling tilting, distancing and positioningmagnetic field generating device in various planes. In an alternativeembodiment the patient may be positioned in the intersection of themagnetic fields generated by the plurality of magnetic field generatingdevices. In the preferred application the at least one applicator may bemovable and the movement may be circular.

The plurality of magnetic field generating devices may be positionedwithin one applicator having form of mechanical holder. The shape of theapplicator having form of mechanical holder may be adjustable, e.g. theapplicator may include at least one moveable part. In a preferredembodiment the applicator having form of mechanical holder may providespatial arrangement of the energy delivery elements in one axis, twoaxes or three axes and/or provide tilting and/or rotation. Theapplicator having form of mechanical holder may provide fixation of theat least one magnetic field generating device in one position. Themoveable parts may be connected by sliding mechanism and/or by a jointmechanism. An exemplary embodiment of such an applicator may be found inU.S. Pat. No. 9,468,774, incorporated herein by reference. Theapplicator may be adjustable following the body region and/or biologicalstructure.

The static position of the at least one applicator may be provided by apositioning member. The positioning member may be e.g. an arm or anadjustable flexible belt. The positioning member may include a bucklefor adjusting the length of the belt. The applicator may be placedwithin predefined locations of the belt. Alternatively the applicatormay be shaped to be moveable along the positioning member, e.g. theshape of the applicator may be preferably concave, e.g. V-shaped orU-shaped. The positioning member may be inserted itself into theconcavity of the applicator. The position of the applicator may beadjusted by limited movement along the positioning member because thepositioning member may be used as guiding member. However, theapplicator may not be fixed to a particular static position. Theposition of the applicator may be dynamically adjusted during thetreatment following the patient's needs. The position of the applicatormay be adjusted manually by the operator, or automatically by thetreatment device. In one exemplary embodiment a plurality of applicatorsmay be used for treating larger body regions, e.g. buttocks, abdomen orthigh.

The present methods may also induce muscle contraction to reduce effectof skin laxity. Skin laxity may be caused by e.g. aging process orincreasing number and/or volume of adipose cells which pulls down theskin by gravity, rapid weight loss or skin stretching during thepregnancy. The muscles may be treated by the induced electric current tocontract. Repetitive contractions may cause the muscles to obtain thetonus and flexibility. Therefore the skin appearance may be enhanced bytreating the flabby muscles. The effect of skin tightening may beachieved. The method also may promote the collagen and elastin fibers inthe layers subtending the epidermis hence the skin may obtain enhancedvisual appearance. The method may be widely applied but not limited toapplication to the regions of neck, breasts, arms or abdomen. The methodmay provide the smoother and younger appearance of the skin to thepatient.

Similar methods of the muscle structure treatment by time-varyingmagnetic field for inducing the at least partial muscle contraction maybe used for treatment of wrinkles as well. Wrinkles are results ofextrinsic and intrinsic factors. Nowadays, wrinkles are considered to benegative effect of natural aging process which decreases the productionof collagen and elastin fibers and weakens the skin which becomesthinner. As the muscle treatment by the magnetic flux density may induceat least partial muscle contraction, the collagen and elastin fibersneogenesis may be improved. Additionally, the muscles subtending thetreated region may be toned and the skin may obtain a younger andenhanced visual appearance. Therefore, the effect of skin tightening maybe achieved.

Wrinkles may be prevented or reduced by practicing facial exerciseswhich may cause a massage effect to the facial tissues, improving bloodand lymph circulation. Additionally, the facial muscles may be relaxedand toned after the exercise. A similar effect as facial exercise may beachieved by non-invasive and/or contactless method of treating thefacial muscles by magnetic flux density. Further additional advantage ofthe present method may be the improvement of restoration of the collagenand elastin fibers, more effective toning and strengthening of thefacial muscles.

The present methods may improve the neogenesis and remodeling ofcollagen fibers in the lips to reach a full, plump and firmerappearance. The magnetic flux density may be applied to the lips by anapplicator. Therefore the lips may become fuller and firmer without anyneed of invasive method such as injection of the synthetic fillers,permanent makeup or the facial implants. The present method may promotethe remodeling and/or neogenesis of collagen fibers in a natural way.Additionally, the collagen is natural substance of the human body whichmay provide the elasticity to the structure.

The present methods may be used for enhancing the visual appearance ofbreasts. Cooper's ligament may be treated, improved and/or firmed by theat least partial muscle contraction. The treatment may induce theelevation of the breast tissue. Additionally, the breast tissue may betreated to be modified in a shape, wherein the shape includes the sizeand/or the contour of the breast tissue. Therefore the visual appearancemay be enhanced and breasts may be more attractive for the patient. Thepresent method may be a non-invasive alternative for current aestheticsurgery method for the treatment of sagging breast tissue. The presentmethod may provide a patient a method of breast visual appearanceenhancement without surgery. Therefore the method lacks post-surgerycomplications such as scars, postoperative pain or long recovery period.Various treatment protocols may be used.

Following the recited methods the treatment may be but is not limited tocontinuous, pulsed, randomized or burst. The impulse may be but notlimited to monophasic, polyphasic, biphasic and/or static magneticfield. In the preferred application the magnetic impulse may be inbiphasic regime, i.e. it is consisted of two phases, preferably positiveand negative.

In the preferred application of the present method the trains of pulses,called bursts are used.

Repetition rate and/or magnetic flux density may vary during thetreatment protocol. Further the treatment may include several periods ofdifferent repetition rates, therefore the modulation may be inrepetition rate domain. The treatment may include several periods ofdifferent magnetic flux densities, therefore the modulation may be inmagnetic flux density domain. Alternatively the treatment may includedifferent impulse durations, therefor the modulation may be in impulseduration domain. In yet another approach the treatment may be modulatedby any combinations thereof.

Various envelopes and/or waveforms, e.g. pulse, sinusoidal, rectangular,square, triangular, saw-tooth, trapezoidal, exponential etc. for thepurpose of muscle treatment may also be used, and are not limited torecited shapes.

The values of magnetic flux density and repetition rate are cited inseveral preferred applications since the perception of the treatment issubjective. Nevertheless, the magnetic flux density and repetition ratesare not limited by the recited values. A person skilled in the physicaltherapy is able to repeat and apply the treatment methods adjusting themagnetic flux density and/or repetition rate following the patient'ssensitivity or needs.

The present method is not limited to be used independently. Forenhancing the result the method may be used in combination with otherconventional non-invasive and/or invasive aesthetic treatment method.

All the recited methods may be applied to a patient in a non-invasiveand/or contactless way. Therefore the present methods provide aneffective alternative approach of enhancing the visual appearance withno need of invasive treatment or surgery. Further, the visual resultsare appreciable after several treatments. Additionally, the resultsinclude not only the visual appearance enhancement but even theimprovement of the muscle structures, hence the patient feels firmer andtighter. The muscle structures become toned with no need of any diet orspending time by exercising in fitness.

The patient may feel firmer and/or tighter. The skin may be alsotighter. Additionally, adipose tissue reduction may occur. Furthermore,cellulite may be reduced as well.

Thus, novel systems and methods have been described. Various changes andsubstitutions may of course be made without departing from the spiritand scope of the invention. The invention, therefore, should not belimited, except by the following claims and their equivalents.

The following U.S. patent applications are incorporated herein byreference: U.S. Ser. Nos. 14/873,110; 14/926,365; 14/951,093;15/073,318; 15/099,274; 15/151,012; 15/178,455; 15/396,073; 15/446,951;15/404,384 and 15/473,390.

Thus, novel apparatus and methods have been shown and described. Variouschanges and substitutions may of course be made without departing fromthe spirit and scope of the invention. The invention, therefore, shouldnot be limited, except by the following claims and their equivalents.

What is claimed is:
 1. A device for treating of a patient, the devicecomprising: an applicator comprising: a magnetic field generating deviceconfigured to generate a time-varying magnetic field, wherein thetime-varying magnetic field comprises a plurality of magnetic biphasicimpulses having an impulse duration in a range of 3 μs to 1000 μs; andan electrode configured to receive the energy for a radiofrequencytreatment to provide radiofrequency waves and apply the radiofrequencywaves to the patient; a high frequency generator configured to provideenergy for a radiofrequency treatment; an energy storage devicecomprising a capacitor configured to provide energy for a magnetictreatment to the magnetic field generating device; and a switchingdevice configured to discharge the energy storage device to the magneticfield generating device in order to generate the time-varying magneticfield, wherein the radiofrequency waves cause heating of the body regionof the patient, and wherein the time-varying magnetic field causes amuscle within the body region of the patient to contract.
 2. The deviceof claim 1, wherein the applicator is configured to be coupled to thepatient by a belt.
 3. The device of claim 1, wherein the device isconfigured to modulate the intensity of the radiofrequency waves.
 4. Thedevice of claim 1, wherein the device is configured to apply magneticimpulses in a protocol, wherein the protocol comprises a treatmentsequence having a repetition rate of magnetic impulses in a range of 5Hz to 50 Hz.
 5. The device of claim 1, wherein the magnetic fieldgenerating device comprises a flat magnetic coil.
 6. The device of claim2, wherein the magnetic field generating device is further configured togenerate the time-varying magnetic field having a magnetic flux densityin a range of 0.8 Tesla to 7 Tesla.
 7. The device of claim 1, whereinthe device is configured to provide a first plurality of magneticimpulses having a first repetition rate and a second plurality ofmagnetic impulses having a second repetition rate, wherein the firstrepetition rate is different than the second repetition rate, andwherein an amplitude of magnetic flux density of the first plurality ofmagnetic impulses is modulated to have a trapezoid shape.
 8. A devicefor treating of a patient, the device comprising: an applicatorcomprising: a radiofrequency electrode configured to provideradiofrequency waves and apply the radiofrequency waves to the patient;a magnetic field generating device configured to generate a time-varyingmagnetic field having a magnetic flux density in a range of 0.8 Tesla to7 Tesla; an inlet configured to direct a cooling fluid into anapplicator to cool the magnetic field generating device, wherein thetime-varying magnetic field further comprises a plurality of biphasicmagnetic impulses having an impulse duration in a range of 3 μs to 1000μs, and wherein the time-varying magnetic field comprises the pluralityof magnetic impulses assembled into a first train and a second train,wherein the first train lasts a time duration in a range of 100millisecond to 100 second; an energy storage device configured toprovide energy for magnetic treatment to the magnetic field generatingdevice; and a switching device configured to discharge the energystorage device to the magnetic field generating device, wherein theradiofrequency waves heat a body region of the patient, and wherein thetime-varying magnetic field causes a muscle of the patient to contract.9. The device of claim 8, wherein the device is configured to provideradiofrequency waves to heat the body region of the patient to thetemperature in a range of 39° C. to 50° C., and wherein the devicefurther comprises a bolus configured to improve homogeneity of thetreatment by radiofrequency waves.
 10. The device of claim 8, whereinthe device is configured to provide the time-varying magnetic field tothe body region.
 11. The device of claim 10, wherein the device isconfigured to modulate the magnetic flux density of the magneticimpulses within the first train, such that an amplitude of magnetic fluxdensity forms a trapezoidal envelope within the first train.
 12. Thedevice of claim 10, wherein the first train comprises 10 to 1000magnetic impulses, wherein the device is configured to stop generationof magnetic impulses between the first train and the second train, andwherein the device is configured to modulate the magnetic flux densityof the magnetic impulses within the first train, such that an amplitudeof magnetic flux density form a rectangular envelope within the firsttrain.
 13. The device of claim 9, wherein the energy storage devicecomprises a capacitor, and wherein the device is configured to apply thetime-varying magnetic field and the radiofrequency waves simultaneously.14. The device of claim 9, further comprising a second applicator,wherein the second applicator comprises a second radiofrequencyelectrode.
 15. The device of claim 8, wherein the cooling fluid is air.16. A device for treating of a patient, the device comprising: anapplicator comprising: a flat magnetic coil configured to apply atime-varying magnetic field to a body region of the patient to cause amuscle within the body region of the patient to contract; and aradiofrequency electrode configured to provide radiofrequency waves andapply the radiofrequency waves to heat the body region of the patient;an energy storage device configured provide energy for a magnetictreatment to the flat magnetic coil; an inlet configured to directcooling fluid into the applicator to cool the flat magnetic coil; and aswitching device configured to discharge the energy storage device tothe flat magnetic coil, wherein the time-varying magnetic fieldcomprises a plurality of magnetic impulses having a repetition rate in arange of 1 Hz to 300 Hz and an impulse duration in a range of 3 μs to1000 μs.
 17. The device of claim 16, wherein the applicator isconfigured to be coupled to the patient by a flexible belt.
 18. Thedevice of claim 16, wherein the device is configured to heat the bodyregion of the patient by radiofrequency waves to the temperature in arange of 39° C. to 50° C.
 19. The device of claim 16, wherein the devicefurther comprises a bolus configured to improve homogeneity of thetreatment by radiofrequency waves.
 20. The device of claim 18, whereinthe energy storage device comprises a capacitor and wherein thetime-varying magnetic field has a magnetic flux density derivative in arange of 0.3 kT/s to 800 kT/s.
 21. The device of claim 20, wherein thedevice is configured to apply magnetic impulses in a protocol, andwherein the protocol comprises a treatment sequence having a repetitionrate of magnetic impulses in a range of 5 Hz to 50 Hz.
 22. The device ofclaim 16, wherein the applicator further comprises an adhesive materialconfigured to fix the applicator in contact with the patient.
 23. Thedevice of claim 20, wherein the inlet is configured to provide a coolingoil or an air.
 24. A method for treatment of a patient, the methodcomprising: switching a switching device to provide energy for magnetictreatment from an energy storage device to a magnetic field generatingdevice, wherein the magnetic field generating device is disposed withinan applicator; providing, by the magnetic field generating device, atime-varying magnetic field comprising a plurality of biphasic magneticimpulses having a magnetic flux density in a range between 0.8 Tesla and7 Tesla, a repetition rate of 1 Hz to 300 Hz and an impulse duration ina range of 3 μs to 1000 μs; applying the plurality of biphasic magneticimpulses of the time-varying magnetic field to a body region of thepatient such that a muscle within the body region is caused to contract;providing radiofrequency waves by a radiofrequency electrode disposedwithin the applicator; applying the radiofrequency waves to the bodyregion of the patient; and heating a biological structure within thebody region by the application of radiofrequency waves.
 25. The methodof claim 24, wherein the biological structure comprises an adiposetissue.
 26. The method of claim 24, further comprising maintaining aposition of the applicator proximate to the body region, wherein thebody region comprises a buttock or an abdomen.
 27. The method of claim24, wherein the biological structure comprises muscle tissue.
 28. Themethod of claim 26, applying the time-varying magnetic fieldsimultaneously with the radiofrequency waves.
 29. The method of claim24, further comprising modulating of an amplitude of the magnetic fluxdensity of time-varying magnetic field into a trapezoidal or arectangular shaped envelope.
 30. The method of claim 26, furthercomprising cooling the magnetic field generating device with a coolingfluid.